The role of miRNA gene variants in susceptibility and pharmacogenetics of colorectal cancer

The role of miRNA gene variants in susceptibility and pharmacogenetics of colorectal cancer

The role of miRNA gene variants in susceptibility and pharmacogenetics of colorectal cancer

Colorectal most cancers (CRC) is likely one of the most important challenges within the subject of most cancers pathology. MiRNAs are among the many genetic elements related to the illness. Though many research have reviewed the expression patterns of assorted miRNAs in CRC, few research have targeted on totally different variants of miRNA.
Within the current evaluate, miRNA variants have been categorized into three subgroups, together with miRNA variants that predict susceptibility to CRC, miRNA variants that predict the medical parameters of CRC and at last, miRNA variants that predict the pharmacological features of CRC. Furthermore, a complete evaluate of probably useful miRNA-associated SNPs in addition to their significance as candidate most cancers biomarkers are mentioned.

Publish-menopausal oestrogen deficiency induces osteoblast apoptosis by way of regulating HOTAIR/miRNA-138 signalling and suppressing TIMP1 expression

On this examine, we aimed to discover the molecular mechanisms underlying the event of osteoporosis in post-menopausal females. Actual-time PCR was performed to measure the expression of potential lncRNAs concerned within the osteoporosis of post-menopausal females. As well as, Western blot and IHC assays had been used to check the doable correlation amongst HOTAIR, miR-138 and TIMP1, whereas a computational evaluation was carried out to foretell the ‘seed sequence’ chargeable for the binding between miR-138 and HOTAIR/TIMP1. Moreover, luciferase reporter assays had been performed to validate the damaging regulatory relationship between miR-138 and TIMP1/HOTAIR. To guage the impact of oestrogen on the perform of HOATIR and its downstream effectors, luciferase exercise was measured in cells cotransfected with totally different vectors or handled with totally different doses of estrogen.
The outcomes of the luciferase assay had been additional validated by real-time PCR, Western blot, MTT assay and movement cytometry. Among the many candidate lncRNAs, HOTAIR was the one lncRNA down-regulated in post-menopausal females. HOTAIR sure to miR-138 and negatively regulated its expression. In the meantime, miR-138 may additionally bind to TIMP1 mRNA and cut back its expression. Moreover, a dose-dependent up-regulation of HOTAIR was noticed in cells handled with oestrogen, and the elevated HOTAIR elevated the extent of TIMP1 by concentrating on miR-138. As well as, oestrogen promoted cell viability and suppressed cell apoptosis, and results of oestrogen had been blocked by the silencing of HOTAIR. Due to this fact, it may be concluded that oestrogen deficiency may induce the apoptosis of osteoblasts and result in osteoporosis in post-menopausal females by way of modulation of the HOTAIR/miR-138/TIMP1 signalling axis.

MicroRNAomes of Cattle Intestinal Tissues Revealed Doable miRNA Regulated Mechanisms Concerned in Escherichia coli O157 Fecal Shedding

Cattle have been steered as the first reservoirs of E. coli O157 primarily on account of colonization of the recto-anal junction (RAJ) and subsequent shedding into the setting. Though a latest examine reported totally different gene expression at RAJ between super-shedders (SS) and non-shedders (NS), the regulatory mechanisms of altered gene expression is unknown. This examine aimed to research whether or not bovine non-coding RNAs play a task in regulating the differentially expressed (DE) genes between SS and NS, thus additional influencing E. coli O157 shedding conduct within the animals via learning miRNAomes of the entire gastrointestinal tract together with duodenum, proximal jejunum, distal jejunum, cecum, spiral colon, descending colon and rectum.
The variety of miRNAs detected in every intestinal area ranged from 390 ± 13 (duodenum) to 413 ± 49 (descending colon). Comparability between SS and NS revealed the variety of differentially expressed (DE) miRNAs ranged from one (in descending colon) to eight (in distal jejunum), and thru the entire intestine, seven miRNAs had been up-regulated and 7 had been down-regulated in SS. The distal jejunum and rectum had been the areas the place probably the most DE miRNAs had been recognized (eight and 7, respectively).
The role of miRNA gene variants in susceptibility and pharmacogenetics of colorectal cancer
The miRNAs, bta-miR-378b, bta-miR-2284j, and bta-miR-2284d had been down-regulated in each distal jejunum and rectum of SS (log2fold-change: -2.7 to -3.8), bta-miR-2887 was down-regulated within the rectum of SS (log2fold-change: -3.2), and bta-miR-211 and bta-miR-29d-3p had been up-regulated within the rectum of SS (log2fold-change: 4.5 and a couple of.2).
Practical evaluation of those miRNAs indicated their potential regulatory function in host immune features, together with hematological system improvement and immune cell trafficking. Our findings counsel that altered expression of miRNA within the intestine of SS might result in differential regulation of immune features concerned in E. coli O157 super-shedding in cattle.

miRNAs derived from circulating small extracellular vesicles as diagnostic biomarkers for nasopharyngeal carcinoma

The microRNAs (miRNAs) in circulating small extracellular vesicles (sEVs) have been steered as potential biomarkers in most cancers analysis. This examine was designed to guage the circulating sEV-derived miRNAs as biomarkers for the analysis of nasopharyngeal carcinoma (NPC). We in contrast the miRNA profiles in plasma-derived sEVs between 16 sufferers with NPC and 5 wholesome controls (HCs). A definite set of miRNAs that had been differentially expressed between sufferers with NPC and HCs was decided utilizing integrative bioinformatics approaches. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment pathway evaluation revealed that the goal genes of the differentially-expressed miRNAs (DEMs) had been primarily concerned in cancer-associated signaling pathways.
Seven consultant DEMs had been chosen and additional validated in extra 60 sufferers with NPC and 40 HCs utilizing quantitative reverse-transcription PCR evaluation (qRT-PCR). Receiver working attribute (ROC) curve evaluation was used to evaluate the accuracy of the sEV-miRNA-based mannequin for analysis. The three-miRNA-based mannequin, comprising miR-134-5p, miR-205-5p, and miR-409-3p, exhibited a well-discriminating energy with an space below the curve (AUC) worth of 0.88 within the coaching set and 0.91 within the validation set.

Multiple stomach tumor with stomach tissue array
ST821 each
EUR 306
Description: Multiple stomach tumor with stomach tissue array, including pathology grade, TNM and clinical stage (reference AJCC 8th version), 80 cases/80 cores

Total RNA - Mouse Normal Tissue: Stomach
R1334248-50 50 ug
EUR 130

Multiple stomach cancer with stomach tissue array
ST2161b each
EUR 546
Description: Multiple stomach cancer with stomach tissue array, including pathology grade, TNM and clinical stage (reference AJCC 7th version), 216 cases/216 cores, replacing ST2161a

Genomic DNA - Mouse Normal Tissue: Stomach
D1334248 100 ug
EUR 286

Stomach Lysate
1415 0.1 mg
EUR 229.2
Description: Stomach tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 50 mM DTT.

Stomach Lysate
1475 0.1 mg
EUR 229.2
Description: Stomach tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 50 mM DTT.

Stomach cancer
ST1451a each
EUR 540
Description: Stomach cancer, matched NAT, matched metastasis tissue (recent year collection samples), including pathology grade, TNM and clinical stage, 71 cases/145 cores, replacing ST1451

Stomach tumor with stomach tissue test tissue array
T012b each
EUR 66
Description: Stomach tumor with stomach tissue test tissue array, including pathology grade, TNM and clinical stage, 12 cases/24 cores, replacing T012a

Stomach cancer (Lauren type) with stomach tissue array
ST2091a each
EUR 546
Description: Stomach cancer (Lauren type) with stomach tissue array, including pathology grade, TNM and clinical stage, 206 cases/208 cores, replacing ST2091

Stomach adenocarcinoma with matched stomach tissue array
ST781 each
EUR 270
Description: Stomach adenocarcinoma with matched stomach tissue array, including pathology grade, TNM and clinical stage, 26 cases/78 cores

Total Protein - Mouse Normal Tissue: Stomach
P1334248 1 mg
EUR 188

Mouse Stomach OptiTDS: Tissue Dissociation System
4-28202 1 Kit Ask for price

mmu-miRNome MicroRNA Profiling Kit [Mouse]
RA670A-1 20 profiles
EUR 2046

Rat Stomach PrimaCell: Normal Stomach Mucosa Epithelial Cells
2-82585 1 Kit Ask for price

Advanced stage of stomach cancer with stomach tissue array
ST963 each
EUR 306
Description: Advanced stage of stomach cancer with stomach tissue array, including pathology grade, TNM and clinical stage (AJCC 7th edition), 95 cases/95 cores,replaced by ST963a

Human Stomach PrimaCell: Normal Stomach Mucosa Epithelial Cells
2-96104 1 Kit Ask for price

Mouse Stomach PrimaCell: Normal Stomach Mucosa Epithelial Cells Growth Supplements with Serum (for 500 ml medium)
9-33088 1 Set Ask for price

Stomach disease spectrum (stomach cancer progression) tissue array
ST1001a each
EUR 306
Description: Stomach disease spectrum (stomach cancer progression) tissue array, including TNM, clinical stage and pathology grade, 100 cases/100 cores, replacing ST1001

Different stages of stomach cancer with stomach tissue array
ST8014 each
EUR 306
Description: Different stages of stomach cancer with stomach tissue array, including pathology grade, TNM and clinical stage, 80 cases/80 cores

cDNA - Lupus: stomach
C1236248Lup 40 reactions
EUR 737

Stomach cancer with matched adjacent normal stomach tissue array
ST244b each
EUR 78
Description: Stomach cancer with matched adjacent normal stomach tissue array, including pathology grade, TNM and clinical stage, 6cases/24cores, replacing ST244a

Advanced stage of stomach adenocarcinoma with stomach tissue array
ST963a each
EUR 306
Description: Advanced stage of stomach adenocarcinoma with stomach tissue array, including pathology grade, TNM and clinical stage, 95 cases/95 cores, replacing ST963

Fetal Stomach Lysate
XBL-10423 0.1 mg
EUR 500.1
Description: Fetal human stomach tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The fetal human stomach tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the stomach tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The stomach tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Stomach signet-ring cell carcinoma array with normal stomach tissue
ST881 each
EUR 306
Description: Stomach signet-ring cell carcinoma array with normal stomach tissue, including TNM and clinical stage, 88 cases/88 cores

Stomach Membrane Lysate
XBL-10924 0.1 mg
EUR 619.8
Description: Human stomach tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human stomach tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated stomach tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated stomach tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Human, Mouse, Rat - Stomach Tissue Array (5 slides/pk)
TAS-1013 1 pk
EUR 343.2

Stomach cancer tissue array with matched adjacent normal stomach tissue
ST801b each
EUR 270
Description: Stomach cancer tissue array with matched adjacent normal stomach tissue, including pathology grade, TNM and clinical stage, 40 cases/80 cores, replacing ST801a

Stomach-Pylorus Lysate
21-325 0.1 mg
EUR 468.6
Description: Monkey (Rhesus) stomach-pylorus tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The monkey (Rhesus) stomach-pylorus tissue total protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the stomach-pylorus tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The stomach-pylorus tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Rat Stomach PrimaCell: Normal Stomach Mucosa Epithelial Cells Growth Medium
9-25085 5 x 100 ml Ask for price

Human Stomach PrimaCell: Normal Stomach Mucosa Epithelial Cells Growth Medium
9-46104 5 x 100 ml Ask for price

Rat Stomach Tissue Preparation Buffer: Normal Stomach Mucosa Epithelial Cells
9-80292 1 x 100 ml Ask for price

Total RNA - Lupus: Stomach
R1236248Lup-50 50 ug
EUR 421.2

Human Stomach Tissue Preparation Buffer: Normal Stomach Mucosa Epithelial Cells
9-80104 1 x 100 ml Ask for price

MicroRNA Isolation Kit
KS341025 1 kit
EUR 247

Stomach Tissue Slide (Tumor)
10-827-10um 10 um
EUR 241.8

Stomach Tissue Slide (Tumor)
10-827-4um 4 um
EUR 216.6

Human Stomach Tumor lysate
HTL-1340 1 mg
EUR 927.6

Immortalized Mouse Stomach Epithelial Cells-Conditionally (ImSt)
T0569 1x106 cells / 1.0 ml Ask for price

Stomach cancer tissue array
BS01012e each
EUR 270
Description: Stomach cancer tissue array, including pathology grade, TNM and clinical stage (AJCC 7th edition), 72 cases/72 cores, replacing BS01012d

Stomach Tissue Slide (Normal)
10-801-10um 10 um
EUR 241.8

Stomach Tissue Slide (Normal)
10-801-4um 4 um
EUR 216.6

Stomach Tissue Slide (Benign)
10-803-10um 10 um
EUR 241.8

Stomach Tissue Slide (Benign)
10-803-4um 4 um
EUR 216.6

Human Stomach Tissue Lysate
30R-AS039 150 ug
EUR 262.8
Description: Fresh tissue lysate isolated from human stomach

Normal stomach tissue array
BN01011b each
EUR 222
Description: Normal stomach tissue array, 24 cases/72 cores, replacing BN01011

Stomach cancer tissue array
ST484d each
EUR 252
Description: Stomach cancer tissue array, including TNM and pathology grade and HER-2 result, 48 cases/48 cores

Stomach Lysate (0 Day Old)
1415-0 0.1 mg
EUR 229.2
Description: Stomach tissue lysate (0 Day Old) was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 50 mM DTT.

Stomach Lysate (14 Day Old)
1415-14 0.1 mg
EUR 229.2
Description: Stomach tissue lysate (14 Day Old) was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 50 mM DTT.

Stomach Lysate (7 Day Old)
1415-7 0.1 mg
EUR 229.2
Description: Stomach tissue lysate (7 Day Old) was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 50 mM DTT.

Stomach Tissue Lysate (Normal)
1717-01 0.1 mg
EUR 260.7
Description: Stomach tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 5% β-mercaptoethanol.

Stomach Tissue Slide (Abnormal)
10-826-10um 10 um
EUR 241.8

Stomach Tissue Slide (Abnormal)
10-826-4um 4 um
EUR 216.6

Stomach Membrane Tumor Lysate
XBL-10936 0.1 mg
EUR 752.1
Description: Human stomach tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human stomach tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated stomach tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated stomach tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Stomach Tissue Slide (Carcinoma)
10-814-10um 10 um
EUR 241.8

Stomach Tissue Slide (Carcinoma)
10-814-4um 4 um
EUR 216.6

Cancer MicroRNA qPCR Array
RA610A-1 10 profiles
EUR 1406.4

Cancer of the stomach, 102 cases (1.5mm)
STC1021 1
EUR 300
Description: Stomach cancer tissue array, 102 cases of normal/benign (5 cases) and cancer (97 cases with grading and TNM staging data) tissues

Cancer of the stomach, 228 cases (1.1mm)
STC2281 1
EUR 552
Description: Stomach cancer tissue array containing 8 cases of normal/benign conditions and 220 cases of cancers with grading and TNM staging data.

Stomach Diabetic Disease Lysate
XBL-10387 0.1 mg
EUR 796.2
Description: Human stomach tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human stomach tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the stomach tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The stomach tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Human microRNA-210(miR-210)ELISA
QY-E05678 96T
EUR 433.2

Mouse Normal Stomach (single section per slide) (5 slides/pack)
MoFPT066 5 slides
EUR 150

Stomach-Cardia Membrane Lysate
XBL-10939 0.1 mg
EUR 619.8
Description: Human stomach: Cardia tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human stomach: Cardia tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated stomach: Cardia tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated stomach: Cardia tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Stomach-Corpus Membrane Lysate
XBL-10942 0.1 mg
EUR 619.8
Description: Human stomach: corpus tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human stomach: corpus tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated stomach: corpus tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated stomach: corpus tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Stomach-Fundus Membrane Lysate
XBL-10945 0.1 mg
EUR 619.8
Description: Human stomach: fundus tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human stomach: fundus tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated stomach: fundus tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated stomach: fundus tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Stomach-Pylorus Membrane Lysate
XBL-10948 0.1 mg
EUR 619.8
Description: Human stomach: Pylorus tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human stomach: Pylorus tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated stomach: Pylorus tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated stomach: Pylorus tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

cDNA - Rat Normal Tissue: Stomach
C1434248 40 reactions
EUR 385

cDNA - Dog Normal Tissue: Stomach
C1734248 40 reactions
EUR 385

Multiple stomach tumor with matched cancer adjacent or adjacent normal stomach tissue array
ST820 each
EUR 306
Description: Multiple stomach tumor with matched cancer adjacent or adjacent normal stomach tissue array, including pathology grade, TNM and clinical stage (reference AJCC 7th version), 40 cases/80 cores

cDNA - Human Tumor Tissue: Stomach
C1235248 40 reactions
EUR 578

Rat Stomach Whole tissue lysate
RAL-1475 1 mg
EUR 628.8

Stomach adenocarcinoma tissue array
BS01011b each
EUR 270
Description: Stomach adenocarcinoma tissue array, including pathology grade, TNM and clinical stage, 72 cases/72 cores, replacing BS01011a

Stomach Tissue Slide (Adenocarcinoma)
10-809-10um 10 um
EUR 241.8

Stomach Tissue Slide (Adenocarcinoma)
10-809-4um 4 um
EUR 216.6

Stomach adenocarcinoma tissue array
ST1502 each
EUR 258
Description: Stomach adenocarcinoma tissue array, including TNM and pathology grade, 75 cases/150 cores

Stomach-Corpus Cytoplasmic Lysate
XBL-10941 0.1 mg
EUR 273.3
Description: Human stomach: corpus tissue cytoplasmic protein lysate was prepared by isolating the cytoplasmic protein from whole tissue homogenates using a proprietary technique. The human stomach: corpus tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The cytoplasmic protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, glycerol, and a cocktail of protease inhibitors. For quality control purposes, the isolated stomach: corpus tissue cytoplasmic protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated stomach: corpus tissue cytoplasmic protein is then Western analyzed by GAPDH antibody, and the expression level is consistent with each lot.

Mouse Stomach FibrOut: Fibroblast Inhibitory System (for 500 ml medium)
7-15181 1 Kit Ask for price

Stomach cancer tissue test array
T011b each
EUR 48
Description: Stomach cancer tissue test array, including pathology grade, TNM and clinical stage, 6 cases/24 cores, replacing T011a

Stomach cancer test tissue array
T014a each
EUR 48
Description: Stomach cancer test tissue array, including pathology grade, TNM and clinical stage, 6 cases/24 cores replacing T014

Epithelial Dissociation System 10 (Stomach epithelial), Mouse and Rat
4-20260 ea Ask for price

Total RNA - Diabetic Disease: Stomach
R1236248Dia-50 50 ug
EUR 421.2

MicroRNA scramble in CD511 - Virus
PMIRH000VA-1 1x10^6 IFUs
EUR 715

Stomach Tissue Slide (Malignant Tumor)
10-807-10um 10 um
EUR 241.8

Stomach Tissue Slide (Malignant Tumor)
10-807-4um 4 um
EUR 216.6

Stomach Tissue Slide (Malignant Tumor)
RF10002-05-10um 10 um
EUR 241.8

Stomach Tissue Slide (Malignant Tumor)
RF10002-05-4um 4 um
EUR 216.6

Total RNA - Rat Normal Tissue: Stomach
R1434248-50 50 ug
EUR 209

Stem Cell MicroRNA Profiling Panel
RA620A-1 10 profiles
EUR 1406.4

Mouse SeraMir Exosome RNA 384 microRNA qPCR Profiler Assay Set (20 assays)
RA811A-1 20 profiles
EUR 469

Microbiomaster Stomacher 80
MIX3002 EACH
EUR 4065.64

Total RNA - Human Tumor Tissue: Stomach
R1235248-50 50 ug
EUR 400

Genomic DNA - Rat Normal Tissue: Stomach
D1434248 100 ug
EUR 286

SanPrep Column microRNA Miniprep Kit
SK8811 50prep
EUR 151.32

cDNA - Human Adult Normal Tissue: Stomach
C1234248 40 reactions
EUR 385

Stomach cancer with normal tissue array
ST2083 each
EUR 546
Description: Stomach cancer with normal tissue array, including pathology grade, TNM and clinical stage, 69 cases/207 cores

Pepsin (3000 U/mg), Porcine Stomach Mucosa
PEP15-01 1 g
EUR 169.2

cDNA - Monkey (Rhesus) Normal Tissue: Stomach
C1534248 40 reactions
EUR 385

Total Protein - Human Tumor Tissue: Stomach
P1235248 1 mg
EUR 310

Rat Stomach PrimaCell: Normal Stomach Mucosa Epithelial Cells Growth Supplements with Serum (for 500 ml medium)
9-26085 1 Set Ask for price

Human Stomach PrimaCell: Normal Stomach Mucosa Epithelial Cells Growth Supplements with Serum (for 500 ml medium)
9-47104 1 Set Ask for price

96 Well Stomach Tumor Genomic DNA Plate
D8235248-1 1 plate
EUR 328

Matched Pair Tissue Slides - Stomach Tissue
10-800-MPPT 1 pack
EUR 241.8
Description: The Matched Pair Paraffin Tissue (MPPT) slides are designed for identifying tumor-specific/metastasis genes or proteins. Slices from normal and malignant tissues are mounted on each MPPT slide which can then be treated as a single histological slide for H&E staining, immunohistochemistry, or in situ hybridization. This format allows a rapid analysis of protein expression and localization across normal and cancerous tissue.

Frozen Tissue Section - Human Tumor: Stomach
T1235248 5 slides
EUR 330

Stomach Tissue Slide (mucinous Adenocarcinoma)
10-810-10um 10 um
EUR 241.8

Stomach Tissue Slide (mucinous Adenocarcinoma)
10-810-4um 4 um
EUR 216.6

MicroRNA Precursor Pooled Plasmid Library
PMIRHPLPA-1 1 aliquot plasmid DNA
EUR 60

cDNA - Human Diabetic Diseased Tissue: Stomach
C1236248Dia 40 reactions
EUR 729

Membrane Protein - Human Tumor Tissue: Stomach
P3235248 0.1 mg
EUR 410

rno-miRNome MicroRNA Profiling Kit [Rat]
RA680B-1 20 complete profiles
EUR 2006.4

Human Cancer PrimaCell16: Stomach Tumor Cells
2-96039 1 Kit Ask for price

cDNA - Monkey (Cynomolgus) Normal Tissue: Stomach
C1534248-Cy 40 reactions
EUR 385

Multiple Species Tissue Slides - Stomach Tissue
10-800-MSTA 1 pack
EUR 241.8
Description: The Multiple Species Tissue Array (MSTA) slides were designed to study protein expression patterns in different cells and tissues from multiple species. Tissue slices from three different species are mounted on each MSTA slide which can then be treated as a single histological slide for H&E staining, immunohistochemistry, or in situ hybridization. This format allows a rapid analysis of protein expression and localization across different species. MSTA slides can also be used to quickly determine the species reactivity of a given antibody.

Cancer of the stomach, 75 cases (1.1mm), set 1
STC1501 1
EUR 300
Description: Stomach cancer tissue array, set 1, non-overlapping with STC1502 or STC1503, 150 cores from normal/benign (5 cases) and cancer (70 cases with grading and TNM staging data) tissues in duplicates

Cancer of the stomach, 75 cases (1.1mm), set 2
STC1502 1
EUR 300
Description: Stomach cancer tissue array, set 2, non-overlapping with STC1501 or STC1503, 150 cores from normal/benign (5 cases) and cancer (70 cases with grading and TNM staging data) tissues in duplicates

Cancer of the stomach, 75 cases (1.1mm), set 3
STC1503 1
EUR 300
Description: Stomach cancer tissue array, set 3, non-overlapping with STC1501 or STC1502, 150 cores from normal/benign (5 cases) and cancer (70 cases with grading and TNM staging data) tissues in duplicates

FFPE Genomic DNA - Human Tumor Tissue: Stomach
D2235248 2 ug
EUR 960

Total RNA - Human Adult Normal Tissue: Stomach
R1234248-50 50 ug
EUR 170

Stomach cancer and lung cancer tissue array
SLC601 each
EUR 306
Description: Stomach cancer and lung cancer tissue array, including TNM and pathology grade, 60 cases/60 cores

hsa-miRNome MicroRNA Profiling Kit [Human]
RA660A-1 20 profiles
EUR 2212.8

Rat Stomach OptiTDS: Tissue Dissociation System
4-28292 1 Kit Ask for price

Stomach carcinoma for antibody screening array
ST1002 each
EUR 306
Description: Stomach carcinoma for antibody screening array, including TNM, clinical stage and pathology grade, 25 cases/100 cores

Common diseases of the stomach, 24 cases (2mm)
STD481 1
EUR 265.2
Description: Stomach disease tissue array, 48 cores, 24 cases of normal, inflammatory and neoplastic conditions of the stomach in duplicates

Stomach Tumor Tissue Array - Duplicated 70 cases covering all the common types of stomach cancer and 5 cases of normal
Z7020046 5 slides
EUR 1657.2
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Stomach Tumor Tissue Array - Duplicated 36 cases covering all the common types of stomach cancer and 12 cases of normal
Z7020048 5 slides
EUR 1657.2
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

cDNA - Human Adult Normal Tissue: Stomach: Cardia
C1234250-10 10 reactions
EUR 215

cDNA - Human Adult Normal Tissue: Stomach: Corpus
C1234251-10 10 reactions
EUR 215

cDNA - Human Adult Normal Tissue: Stomach: Fundus
C1234252-10 10 reactions
EUR 215

Total RNA - Monkey (Rhesus) Normal Tissue: Stomach
R1534248-50 50 ug
EUR 191

Human Stomach OptiTDS: Tissue Dissociation System
4-28104 1 Kit Ask for price

cDNA - Human Adult Normal Tissue: Stomach: Pylorus
C1234253-10 10 reactions
EUR 215

Human Adult Stomach (Normal) Whole tissue lysate
HAL-1319 1 mg
EUR 628.8

Monkey (Cyno.) Normal Stomach Whole tissue lysate
MCL-1210 1 mg
EUR 628.8

Different stage of stomach cancer tissue array
ST1921 each
EUR 474
Description: Different stage of stomach cancer tissue array, including pathology grade, TNM and clinical stage, 96 cases/192 cores

miRZip-1 anti-miR-1 microRNA construct
MZIP1-PA-1 Bacterial Streak
EUR 620

miRZip-7 anti-miR-7 microRNA construct
MZIP7-PA-1 Bacterial Streak
EUR 620

miRZip-9 anti-miR-9 microRNA construct
MZIP9-PA-1 Bacterial Streak
EUR 620

Human Stomach Tissue Slide (Tumor) (5 slides/pk)
HTS-10827 1 pk
EUR 343.2

Stomach Tumor Tissue Array - Duplicated 70 cases covering all the common types of stomach cancer and 5 cases of normal a
Z7020045 5 slides
EUR 1657.2
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

cDNA - Monkey (Rhesus) Normal Tissue: Stomach: Cardia
C1534250 40 reactions
EUR 578

cDNA - Monkey (Rhesus) Normal Tissue: Stomach: Corpus
C1534251 40 reactions
EUR 578

cDNA - Monkey (Rhesus) Normal Tissue: Stomach: Fundus
C1534252 40 reactions
EUR 578

Total Protein - Human Adult Normal Tissue: Stomach
P1234248 1 mg
EUR 188

Stomach cancer and adjacent normal tissue array
ST8015 each
EUR 306
Description: Stomach cancer and adjacent normal tissue array, including TNM and pathology grade, 80 cases/80 cores

Normal stomach tissue and duodenum tissue array
SIN241 each
EUR 198
Description: Normal stomach tissue and duodenum tissue array, 24 cases/ 24 cores

Genomic DNA - Lupus: Stomach, from a single donor
D1236248Lup 50 ug
EUR 504

Human Stomach Tissue Slide (Normal) (5 slides/pk)
HTS-10801 1 pk
EUR 343.2

Human Stomach Tissue Slide (Benign) (5 slides/pk)
HTS-10803 1 pk
EUR 343.2
Moreover, the diagnostic mannequin had a wonderful classification capability in distinguishing sufferers with NPC at totally different medical phases or Epstein-Barr virus an infection standing from HCs. In conclusion, our findings indicated that sEV-derived miRNA ranges had been altered within the plasma of sufferers with NPC compared with these in HCs. The mannequin primarily based on the three sEV-derived miRNAs may doubtlessly act as a substitute or complementary strategy for diagnosing NPC.
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