The role of miRNA gene variants in susceptibility and pharmacogenetics of colorectal cancer

The role of miRNA gene variants in susceptibility and pharmacogenetics of colorectal cancer

The role of miRNA gene variants in susceptibility and pharmacogenetics of colorectal cancer

Colorectal most cancers (CRC) is likely one of the most important challenges within the subject of most cancers pathology. MiRNAs are among the many genetic elements related to the illness. Though many research have reviewed the expression patterns of assorted miRNAs in CRC, few research have targeted on totally different variants of miRNA.
Within the current evaluate, miRNA variants have been categorized into three subgroups, together with miRNA variants that predict susceptibility to CRC, miRNA variants that predict the medical parameters of CRC and at last, miRNA variants that predict the pharmacological features of CRC. Furthermore, a complete evaluate of probably useful miRNA-associated SNPs in addition to their significance as candidate most cancers biomarkers are mentioned.

Publish-menopausal oestrogen deficiency induces osteoblast apoptosis by way of regulating HOTAIR/miRNA-138 signalling and suppressing TIMP1 expression

On this examine, we aimed to discover the molecular mechanisms underlying the event of osteoporosis in post-menopausal females. Actual-time PCR was performed to measure the expression of potential lncRNAs concerned within the osteoporosis of post-menopausal females. As well as, Western blot and IHC assays had been used to check the doable correlation amongst HOTAIR, miR-138 and TIMP1, whereas a computational evaluation was carried out to foretell the ‘seed sequence’ chargeable for the binding between miR-138 and HOTAIR/TIMP1. Moreover, luciferase reporter assays had been performed to validate the damaging regulatory relationship between miR-138 and TIMP1/HOTAIR. To guage the impact of oestrogen on the perform of HOATIR and its downstream effectors, luciferase exercise was measured in cells cotransfected with totally different vectors or handled with totally different doses of estrogen.
The outcomes of the luciferase assay had been additional validated by real-time PCR, Western blot, MTT assay and movement cytometry. Among the many candidate lncRNAs, HOTAIR was the one lncRNA down-regulated in post-menopausal females. HOTAIR sure to miR-138 and negatively regulated its expression. In the meantime, miR-138 may additionally bind to TIMP1 mRNA and cut back its expression. Moreover, a dose-dependent up-regulation of HOTAIR was noticed in cells handled with oestrogen, and the elevated HOTAIR elevated the extent of TIMP1 by concentrating on miR-138. As well as, oestrogen promoted cell viability and suppressed cell apoptosis, and results of oestrogen had been blocked by the silencing of HOTAIR. Due to this fact, it may be concluded that oestrogen deficiency may induce the apoptosis of osteoblasts and result in osteoporosis in post-menopausal females by way of modulation of the HOTAIR/miR-138/TIMP1 signalling axis.

MicroRNAomes of Cattle Intestinal Tissues Revealed Doable miRNA Regulated Mechanisms Concerned in Escherichia coli O157 Fecal Shedding

Cattle have been steered as the first reservoirs of E. coli O157 primarily on account of colonization of the recto-anal junction (RAJ) and subsequent shedding into the setting. Though a latest examine reported totally different gene expression at RAJ between super-shedders (SS) and non-shedders (NS), the regulatory mechanisms of altered gene expression is unknown. This examine aimed to research whether or not bovine non-coding RNAs play a task in regulating the differentially expressed (DE) genes between SS and NS, thus additional influencing E. coli O157 shedding conduct within the animals via learning miRNAomes of the entire gastrointestinal tract together with duodenum, proximal jejunum, distal jejunum, cecum, spiral colon, descending colon and rectum.
The variety of miRNAs detected in every intestinal area ranged from 390 ± 13 (duodenum) to 413 ± 49 (descending colon). Comparability between SS and NS revealed the variety of differentially expressed (DE) miRNAs ranged from one (in descending colon) to eight (in distal jejunum), and thru the entire intestine, seven miRNAs had been up-regulated and 7 had been down-regulated in SS. The distal jejunum and rectum had been the areas the place probably the most DE miRNAs had been recognized (eight and 7, respectively).
The role of miRNA gene variants in susceptibility and pharmacogenetics of colorectal cancer
The miRNAs, bta-miR-378b, bta-miR-2284j, and bta-miR-2284d had been down-regulated in each distal jejunum and rectum of SS (log2fold-change: -2.7 to -3.8), bta-miR-2887 was down-regulated within the rectum of SS (log2fold-change: -3.2), and bta-miR-211 and bta-miR-29d-3p had been up-regulated within the rectum of SS (log2fold-change: 4.5 and a couple of.2).
Practical evaluation of those miRNAs indicated their potential regulatory function in host immune features, together with hematological system improvement and immune cell trafficking. Our findings counsel that altered expression of miRNA within the intestine of SS might result in differential regulation of immune features concerned in E. coli O157 super-shedding in cattle.

miRNAs derived from circulating small extracellular vesicles as diagnostic biomarkers for nasopharyngeal carcinoma

The microRNAs (miRNAs) in circulating small extracellular vesicles (sEVs) have been steered as potential biomarkers in most cancers analysis. This examine was designed to guage the circulating sEV-derived miRNAs as biomarkers for the analysis of nasopharyngeal carcinoma (NPC). We in contrast the miRNA profiles in plasma-derived sEVs between 16 sufferers with NPC and 5 wholesome controls (HCs). A definite set of miRNAs that had been differentially expressed between sufferers with NPC and HCs was decided utilizing integrative bioinformatics approaches. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment pathway evaluation revealed that the goal genes of the differentially-expressed miRNAs (DEMs) had been primarily concerned in cancer-associated signaling pathways.
Seven consultant DEMs had been chosen and additional validated in extra 60 sufferers with NPC and 40 HCs utilizing quantitative reverse-transcription PCR evaluation (qRT-PCR). Receiver working attribute (ROC) curve evaluation was used to evaluate the accuracy of the sEV-miRNA-based mannequin for analysis. The three-miRNA-based mannequin, comprising miR-134-5p, miR-205-5p, and miR-409-3p, exhibited a well-discriminating energy with an space below the curve (AUC) worth of 0.88 within the coaching set and 0.91 within the validation set.

Multiple stomach cancer with stomach tissue array

ST2161b each
EUR 546
Description: Multiple stomach cancer with stomach tissue array, including pathology grade, TNM and clinical stage (reference AJCC 7th version), 216 cases/216 cores, replacing ST2161a

Stomach adenocarcinoma with matched stomach tissue array

ST781 each
EUR 270
Description: Stomach adenocarcinoma with matched stomach tissue array, including pathology grade, TNM and clinical stage, 26 cases/78 cores

Multiple stomach tumor with stomach tissue array

ST821 each
EUR 306
Description: Multiple stomach tumor with stomach tissue array, including pathology grade, TNM and clinical stage (reference AJCC 8th version), 80 cases/80 cores

Mouse Stomach Whole tissue lysate

MAL-1415 1 mg
EUR 628.8

Rat Stomach PrimaCell: Normal Stomach Mucosa Epithelial Cells

2-82585 1 Kit Ask for price

Human Stomach PrimaCell: Normal Stomach Mucosa Epithelial Cells

2-96104 1 Kit Ask for price

Stomach disease spectrum (stomach cancer progression) tissue array

ST1001a each
EUR 306
Description: Stomach disease spectrum (stomach cancer progression) tissue array, including TNM, clinical stage and pathology grade, 100 cases/100 cores, replacing ST1001

Stomach cancer (Lauren type) with stomach tissue array

ST2091a each
EUR 546
Description: Stomach cancer (Lauren type) with stomach tissue array, including pathology grade, TNM and clinical stage, 206 cases/208 cores, replacing ST2091

Stomach tumor with stomach tissue test tissue array

T012b each
EUR 66
Description: Stomach tumor with stomach tissue test tissue array, including pathology grade, TNM and clinical stage, 12 cases/24 cores, replacing T012a

Stomach-Pylorus Lysate

21-325 0.1 mg
EUR 468.6
Description: Monkey (Rhesus) stomach-pylorus tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The monkey (Rhesus) stomach-pylorus tissue total protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the stomach-pylorus tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The stomach-pylorus tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Fetal Stomach Lysate

XBL-10423 0.1 mg
EUR 500.1
Description: Fetal human stomach tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The fetal human stomach tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the stomach tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The stomach tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Stomach Membrane Lysate

XBL-10924 0.1 mg
EUR 619.8
Description: Human stomach tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human stomach tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated stomach tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated stomach tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Mouse Stomach OptiTDS: Tissue Dissociation System

4-28202 1 Kit Ask for price

cDNA from Mouse Normal Tissue: Stomach

C1334248 40 reactions
EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Stomach cancer with matched adjacent normal stomach tissue array

ST244b each
EUR 78
Description: Stomach cancer with matched adjacent normal stomach tissue array, including pathology grade, TNM and clinical stage, 6cases/24cores, replacing ST244a

Different stages of stomach cancer with stomach tissue array

ST8014 each
EUR 306
Description: Different stages of stomach cancer with stomach tissue array, including pathology grade, TNM and clinical stage, 80 cases/80 cores

Advanced stage of stomach cancer with stomach tissue array

ST963 each
EUR 306
Description: Advanced stage of stomach cancer with stomach tissue array, including pathology grade, TNM and clinical stage (AJCC 7th edition), 95 cases/95 cores,replaced by ST963a

Advanced stage of stomach adenocarcinoma with stomach tissue array

ST963a each
EUR 306
Description: Advanced stage of stomach adenocarcinoma with stomach tissue array, including pathology grade, TNM and clinical stage, 95 cases/95 cores, replacing ST963

Rat Stomach PrimaCell: Normal Stomach Mucosa Epithelial Cells Growth Medium

9-25085 5 x 100 ml Ask for price

Human Stomach PrimaCell: Normal Stomach Mucosa Epithelial Cells Growth Medium

9-46104 5 x 100 ml Ask for price

Human Stomach Tissue Preparation Buffer: Normal Stomach Mucosa Epithelial Cells

9-80104 1 x 100 ml Ask for price

Rat Stomach Tissue Preparation Buffer: Normal Stomach Mucosa Epithelial Cells

9-80292 1 x 100 ml Ask for price

Stomach cancer tissue array with matched adjacent normal stomach tissue

ST801b each
EUR 270
Description: Stomach cancer tissue array with matched adjacent normal stomach tissue, including pathology grade, TNM and clinical stage, 40 cases/80 cores, replacing ST801a

Stomach signet-ring cell carcinoma array with normal stomach tissue

ST881 each
EUR 306
Description: Stomach signet-ring cell carcinoma array with normal stomach tissue, including TNM and clinical stage, 88 cases/88 cores

Stomach Tissue Slide (Normal)

10-801-10um 10 um
EUR 241.8

Stomach Tissue Slide (Normal)

10-801-4um 4 um
EUR 216.6

Stomach Tissue Slide (Benign)

10-803-10um 10 um
EUR 241.8

Stomach Tissue Slide (Benign)

10-803-4um 4 um
EUR 216.6

Stomach Tissue Slide (Adenocarcinoma)

10-809-10um 10 um
EUR 241.8

Stomach Tissue Slide (Adenocarcinoma)

10-809-4um 4 um
EUR 216.6

Stomach Tissue Slide (Carcinoma)

10-814-10um 10 um
EUR 241.8

Stomach Tissue Slide (Carcinoma)

10-814-4um 4 um
EUR 216.6

Stomach Tissue Slide (Abnormal)

10-826-10um 10 um
EUR 241.8

Stomach Tissue Slide (Abnormal)

10-826-4um 4 um
EUR 216.6

Stomach Tissue Slide (Tumor)

10-827-10um 10 um
EUR 241.8

Stomach Tissue Slide (Tumor)

10-827-4um 4 um
EUR 216.6

Human Stomach Tissue Lysate

30R-AS039 150 ug
EUR 262.8
Description: Fresh tissue lysate isolated from human stomach

Stomach Tissue Lysate (Normal)

1717-01 0.1 mg
EUR 260.7
Description: Stomach tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 5% β-mercaptoethanol.

cDNA from Lupus: stomach

C1236248Lup 40 reactions
EUR 801.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Human Stomach Tumor lysate

HTL-1340 1 mg
EUR 927.6

Stomach Diabetic Disease Lysate

XBL-10387 0.1 mg
EUR 796.2
Description: Human stomach tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human stomach tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the stomach tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The stomach tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Stomach Membrane Tumor Lysate

XBL-10936 0.1 mg
EUR 752.1
Description: Human stomach tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human stomach tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated stomach tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated stomach tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Stomach-Cardia Membrane Lysate

XBL-10939 0.1 mg
EUR 619.8
Description: Human stomach: Cardia tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human stomach: Cardia tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated stomach: Cardia tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated stomach: Cardia tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Stomach-Corpus Cytoplasmic Lysate

XBL-10941 0.1 mg
EUR 273.3
Description: Human stomach: corpus tissue cytoplasmic protein lysate was prepared by isolating the cytoplasmic protein from whole tissue homogenates using a proprietary technique. The human stomach: corpus tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The cytoplasmic protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, glycerol, and a cocktail of protease inhibitors. For quality control purposes, the isolated stomach: corpus tissue cytoplasmic protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated stomach: corpus tissue cytoplasmic protein is then Western analyzed by GAPDH antibody, and the expression level is consistent with each lot.

Stomach-Corpus Membrane Lysate

XBL-10942 0.1 mg
EUR 619.8
Description: Human stomach: corpus tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human stomach: corpus tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated stomach: corpus tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated stomach: corpus tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Stomach-Fundus Membrane Lysate

XBL-10945 0.1 mg
EUR 619.8
Description: Human stomach: fundus tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human stomach: fundus tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated stomach: fundus tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated stomach: fundus tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Stomach-Pylorus Membrane Lysate

XBL-10948 0.1 mg
EUR 619.8
Description: Human stomach: Pylorus tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human stomach: Pylorus tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated stomach: Pylorus tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated stomach: Pylorus tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Normal stomach tissue array

BN01011b each
EUR 222
Description: Normal stomach tissue array, 24 cases/72 cores, replacing BN01011

Stomach adenocarcinoma tissue array

BS01011b each
EUR 270
Description: Stomach adenocarcinoma tissue array, including pathology grade, TNM and clinical stage, 72 cases/72 cores, replacing BS01011a

Stomach cancer tissue array

BS01012e each
EUR 270
Description: Stomach cancer tissue array, including pathology grade, TNM and clinical stage (AJCC 7th edition), 72 cases/72 cores, replacing BS01012d

Stomach adenocarcinoma tissue array

ST1502 each
EUR 258
Description: Stomach adenocarcinoma tissue array, including TNM and pathology grade, 75 cases/150 cores

Stomach cancer tissue array

ST484d each
EUR 252
Description: Stomach cancer tissue array, including TNM and pathology grade and HER-2 result, 48 cases/48 cores

Stomach adenocarcinoma tissue microarray

ST991b each
EUR 270
Description: Stomach adenocarcinoma tissue microarray, including TNM, clinical stage and pathology grade, 33 cases/ 99cores, replacing ST991a

Genomic DNA from Mouse Normal Tissue: Stomach

D1334248 100 ug
EUR 338.4
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total Protein from Mouse Normal Tissue: Stomach

P1334248 1 mg
EUR 256.8
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Immortalized Mouse Stomach Epithelial Cells-Conditionally (ImSt)

T0569 1x106 cells / 1.0 ml Ask for price

Total RNA from Mouse Normal Tissue: Stomach

R1334248-50 50 ug
EUR 182.4
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Mouse Stomach PrimaCell: Normal Stomach Mucosa Epithelial Cells Growth Supplements with Serum (for 500 ml medium)

9-33088 1 Set Ask for price

Stomach Tissue Slide (Malignant Tumor)

10-807-10um 10 um
EUR 241.8

Stomach Tissue Slide (Malignant Tumor)

10-807-4um 4 um
EUR 216.6

Stomach Tissue Slide (mucinous Adenocarcinoma)

10-810-10um 10 um
EUR 241.8

Stomach Tissue Slide (mucinous Adenocarcinoma)

10-810-4um 4 um
EUR 216.6

Stomach Lysate (0 Day Old)

1415-0 0.1 mg
EUR 229.2
Description: Stomach tissue lysate (0 Day Old) was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 50 mM DTT.

Stomach Lysate (14 Day Old)

1415-14 0.1 mg
EUR 229.2
Description: Stomach tissue lysate (14 Day Old) was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 50 mM DTT.

Stomach Lysate (7 Day Old)

1415-7 0.1 mg
EUR 229.2
Description: Stomach tissue lysate (7 Day Old) was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 50 mM DTT.

Total RNA from Lupus: Stomach

R1236248Lup-50 50 ug
EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Stomach Tissue Slide (Malignant Tumor)

RF10002-05-10um 10 um
EUR 241.8

Stomach Tissue Slide (Malignant Tumor)

RF10002-05-4um 4 um
EUR 216.6

Rat Stomach Whole tissue lysate

RAL-1475 1 mg
EUR 628.8

Stomach cancer tissue test array

T011b each
EUR 48
Description: Stomach cancer tissue test array, including pathology grade, TNM and clinical stage, 6 cases/24 cores, replacing T011a

Stomach cancer test tissue array

T014a each
EUR 48
Description: Stomach cancer test tissue array, including pathology grade, TNM and clinical stage, 6 cases/24 cores replacing T014

mmu-miRNome MicroRNA Profiling Kit [Mouse]

RA670A-1 20 profiles
EUR 2046

MicroRNA Isolation Kit

KS341025 1 kit
EUR 307.2
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Multiple stomach tumor with matched cancer adjacent or adjacent normal stomach tissue array

ST820 each
EUR 306
Description: Multiple stomach tumor with matched cancer adjacent or adjacent normal stomach tissue array, including pathology grade, TNM and clinical stage (reference AJCC 7th version), 40 cases/80 cores

Epithelial Dissociation System 10 (Stomach epithelial), Mouse and Rat

4-20260 ea Ask for price

Human, Mouse, Rat - Stomach Tissue Array (5 slides/pk)

TAS-1013 1 pk
EUR 343.2

Mouse pre-microRNA Expression Construct mir-100

MMIR-100-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-101a

MMIR-101a-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-101b

MMIR-101b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-101c

MMIR-101c-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-105

MMIR-105-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-106a

MMIR-106a-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-106b

MMIR-106b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-107

MMIR-107-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-10a

MMIR-10a-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-10b

MMIR-10b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-122

MMIR-122-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-125a

MMIR-125a-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-126

MMIR-126-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-127

MMIR-127-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-130a

MMIR-130a-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-130b

MMIR-130b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-132

MMIR-132-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-133b

MMIR-133b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-134

MMIR-134-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-135b

MMIR-135b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-136

MMIR-136-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-139

MMIR-139-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-140

MMIR-140-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-141

MMIR-141-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-142

MMIR-142-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-143

MMIR-143-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-145

MMIR-145-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-146a

MMIR-146a-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-146b

MMIR-146b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-148a

MMIR-148a-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-149

MMIR-149-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-150

MMIR-150-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-151

MMIR-151-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-152

MMIR-152-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-153

MMIR-153-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-154

MMIR-154-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-155

MMIR-155-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-181c

MMIR-181c-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-181d

MMIR-181d-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-182

MMIR-182-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-183

MMIR-183-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-184

MMIR-184-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-185

MMIR-185-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-186

MMIR-186-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-187

MMIR-187-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-188

MMIR-188-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-18b

MMIR-18b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-190

MMIR-190-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-190b

MMIR-190b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-191

MMIR-191-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-192

MMIR-192-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-193

MMIR-193-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-193b

MMIR-193b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-195

MMIR-195-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-196b

MMIR-196b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-1b

MMIR-1b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-200a

MMIR-200a-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-200b

MMIR-200b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-200c

MMIR-200c-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-201

MMIR-201-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-202

MMIR-202-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-203

MMIR-203-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-204

MMIR-204-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-205

MMIR-205-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-206

MMIR-206-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-207

MMIR-207-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-208a

MMIR-208a-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-208b

MMIR-208b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-20b

MMIR-20b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-21

MMIR-21-PA-1 Bacterial Streak
EUR 820.8
Moreover, the diagnostic mannequin had a wonderful classification capability in distinguishing sufferers with NPC at totally different medical phases or Epstein-Barr virus an infection standing from HCs. In conclusion, our findings indicated that sEV-derived miRNA ranges had been altered within the plasma of sufferers with NPC compared with these in HCs. The mannequin primarily based on the three sEV-derived miRNAs may doubtlessly act as a substitute or complementary strategy for diagnosing NPC.

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